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KMID : 0984720070390050248
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Infection and Chemotherapy
2007 Volume.39 No. 5 p.248 ~ p.254
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Epidemiology of Candidemia in Neonates and Children: Asingle Center Experience from 2001 to 2006
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Lee Taek-Jin
Kim Dong-Soo
Chun Jin-Kyoung
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Abstract
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Purpose: We evaluated epidemiological and clinical features of candidemia in neonates and children.
Methods: We retrospectively reviewed the medical charts of hospitalized neonates and children with positive blood cultures for Candida species from September 1, 2000 through August 31, 2006.
Results: Among 39 total neonates and children with candidemia, the median age was 4 months (interquartile range, 1-28) and overall mortality was 33%. Candida species included: Candida albicans (56%), Candida parapsilosis (23%) and Candida glabrata (15%). There was a tendency of proportional increase of candidemia due to non-albicans species (13% in 2001 vs 91% in 2006; P = 0.01). Compared with children older than 1 month of age, the proportion of C. parapsilosis was significantly higher in neonates with candidemia (58% vs 7%; P = 0.001). C. albicans was isolated more commonly from those who had undergone surgical intervention before candidemia (55% vs 18%; P < 0.05). C. parapsilosis was isolated more commonly from premature neonates (78% vs 27%; P = 0.015). C. glabrata was isolated more commonly from those who had neutropenia before candidemia (67% vs 12%; P = 0.011).
Conclusions: Candidemia by C. albicans was more commonly in surgical patients; by C. parapsilosis in premature neonates; by C. glabrata in neutropenic patients.
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KEYWORD
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Candidemia, Invasive candidiasis, Fungal infection, Pediatric, Risk factors
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